دکتر محمدتقی فرزادفرد
فلوشیپ فوق تخصصی صرع
تازههای صرع
آخرین یافتههای علمی و مقالات منتشر شده در PubMed
EEGEpochNet: Self-supervised contrastive learning for automated EEG epoch rejection with multi-level feature construction
Mon, 23 Feb 2026 06:00:00 -0500
OBJECTIVE: Raw Electroencephalography (EEG) requires robust rejection of inevitable bad EEG epochs to ensure data reliability. While automated methods reduce manual inspection burdens, existing approaches struggle with parameter optimization, scenario adaptation, and label dependency. This study presents EEGEpochNet, an end-to-end model for accurate bad EEG epoch rejection.
Stent-Based Electrode for Long-Term Intracranial EEG Recording in Sheep: A Preliminary Study
Mon, 23 Feb 2026 06:00:00 -0500
No abstract
Extreme delta brush EEG pattern in anti-NMDA receptor encephalitis
Mon, 23 Feb 2026 06:00:00 -0500
No abstract
Epilepsy, Ethics, Ethnicity: "Making and Unmaking" Elsie Lacks at Crownsville State Hospital in The Immortal Life of Henrietta Lacks
Mon, 23 Feb 2026 06:00:00 -0500
Throughout African American medical history, Black epileptic women have been rendered unwillingly invisible, both as enslaved persons and as patients, and were often construed as defective, resistant, malingering, or disabled. A challenge therefore arises for bioethics scholarship when modern, white-dominated psychiatric institutions conceal the impairment of Black epileptic women within the malleable demarcation of disability. The article advances two distinct yet interrelated perspectives on...
Naringenin-Loaded PCL Nanoparticles Attenuate Glial Activation and TNF-alpha Expression in Iron-Induced Post-traumatic Epilepsy
Mon, 23 Feb 2026 06:00:00 -0500
No abstract
EEG, clinical, and MRI features of status epilepticus associated with mitochondrial diseases
Mon, 23 Feb 2026 06:00:00 -0500
CONCLUSION: SE is a severe complication of mitochondrial diseases. Three main EEG patterns were identified across episodes. Correlation with MRI suggests two mechanisms: (i) neuronal dysfunction generate rhythmic SE patterns that subsequently induce stroke-like lesions, due to increased local energy demands, and (ii) in more severe cases, acute bioenergetic failure and stroke-like lesions may directly trigger a specific EEG pattern, prolonging SE duration.
Decoding EEG Signals for Brain-Computer Interfaces
Mon, 23 Feb 2026 06:00:00 -0500
Electroencephalography (EEG) is a non-invasive technique that records brain electrical activity, providing critical insights into neural processes. In recent years, EEG has become integral to brain-computer interface (BCI) research. BCIs enhance human-computer interaction, support assistive solutions for people with disabilities, and enable novel clinical applications. Research in EEG-based BCIs involves several key components: signal acquisition, preprocessing, feature extraction, and...
Pneumocephalus and Seizure Post Cranioplasty: A Case Report
Mon, 23 Feb 2026 06:00:00 -0500
Pneumocephalus is a condition characterized by the presence of air within the intracranial space and can be classified as either simple or tension. It is associated with various etiologies, ranging from infectious causes to craniofacial surgical procedures such as cranioplasty. We report the case of a 28-year-old male patient with no previous comorbidities who after sustaining a gunshot wound to the head, underwent a cranioplasty for facial reconstruction under general anesthesia. During the...
Feasibility of Electroencephalography-Based Detection of Single-Flash Microperimetry Stimuli: A Proof-of-Concept Study
Mon, 23 Feb 2026 06:00:00 -0500
CONCLUSION: These findings demonstrate the feasibility of detecting single-flash MP stimuli from occipital EEG using deep learning, even under constrained acquisition conditions. While not intended for immediate clinical deployment, this work motivates future studies incorporating precise synchronization, optimized stimulus designs, and larger cohorts to evaluate EEG-augmented microperimetry as a potential objective adjunct to subjective functional testing.
Comprehensive evaluation of EEG spatial sampling, head modelling and parcellation effects on network alterations in idiopathic generalized epilepsy
Mon, 23 Feb 2026 06:00:00 -0500
Idiopathic generalized epilepsy is characterized by marked brain network alterations as assessed using electrophysiology. Logistical challenges and the need for a volumetric MRI often hinder the clinical application of high-density EEG or magnetoencephalography. This study investigates the influence of EEG channel density and the head model on brain metrics derived from 256-channel EEG and 19-channel routine EEG in two samples balanced for age and sex. First, we evaluated resting-state data from...
MountPat: investigations on the EEG signals
Mon, 23 Feb 2026 06:00:00 -0500
To extract information from the brain, the most cost-effective method is electroencephalography (EEG) signal acquisition. Therefore, many researchers have used EEG signals to capture brain activity. EEG signals are complex; hence, computer-aided models-especially machine learning (ML)-are generally employed to interpret them. The primary objective of this research is to demonstrate the feature-extraction capability of a new, novel method. The proposed feature-extraction approach employs a...
Antiseizure monotherapy with imepitoin or phenobarbital in feline idiopathic epilepsy: a multicenter, single-blinded, randomized and placebo-controlled study
Mon, 23 Feb 2026 06:00:00 -0500
In feline idiopathic epilepsy (IE), the options for antiseizure medications (ASMs) remain limited with no licensed drugs available in cats in Europe. This study aimed to evaluate and compare efficacy and safety of imepitoin and phenobarbital through a multicenter, single-blinded, randomized, placebo-controlled trial. A total of 37 cats were included in this study. The study treatment evaluation period lasted for 15 weeks. In the imepitoin group (n = 16), monthly seizure frequency was...
Multimodal neuroimaging discrimination of Alzheimer's disease, mild cognitive impairment, and late-life depression using electroencephalography and functional near-infrared spectroscopy: integrating electrophysiological and hemodynamic biomarkers
Mon, 23 Feb 2026 06:00:00 -0500
CONCLUSION: These findings highlight distinct EEG spectral patterns in patients with LLD compared to those with AD or MCI, particularly in alpha and high-gamma oscillations. These differences could be potential biomarkers for differentiating these conditions. Combining EEG and fNIRS analyses may further elucidate the neurophysiological mechanisms underlying these disorders.
Neural signature of human-dog interactions: EEG correlates from comparisons with plant and replica dog in a within-subject, cross-over randomized trial
Mon, 23 Feb 2026 06:00:00 -0500
CONCLUSION: These findings provide novel electrophysiological evidence that interacting with a real dog elicits unique oscillatory patterns distinct from those observed with non-sentient-living or non-living-controls. The results highlight the social and emotional salience of animals and advance understanding of the neurocognitive mechanisms underlying human-animal interactions, with implications for applied contexts such as animal-assisted treatments.
Matched tissue-blood whole-exome sequencing improves detection of genetic etiologies in pediatric drug-resistant epilepsy
Mon, 23 Feb 2026 06:00:00 -0500
CONCLUSIONS: Matched tissue-blood WES facilitates the diagnostic yield in pediatric drug-resistant epilepsy, highlighting its critical value in detecting genetic variants that may be missed by blood-only testing and providing essential support for precision diagnosis and therapy.
Postoperative Seizure in Patients with Malignant Glioma Undergoing Tumor Resection with Intraoperative Mapping: Risk Factors, Management Strategies, and the Utility of Bayesian Analysis in a Case-Control Cohort
Mon, 23 Feb 2026 06:00:00 -0500
BACKGROUND Postoperative seizures can occur secondary to cortical irritation from malignant glioma resection or from direct electrical stimulation of the cortical surface during intraoperative brain mapping. A paucity of literature exists with regards to the use of appropriate seizure risk-reduction strategies for this patient population. The objective of the study was to identify primary risk factors for early and late postoperative seizures following intraoperative brain mapping. METHODS The...
Interpretable Feature-Transformer Framework for Cross-Subject MCI Detection Using Nonlinear Dynamical and Graph-Theoretic EEG Features
Mon, 23 Feb 2026 06:00:00 -0500
Early and accurate detection of Mild Cognitive Impairment (MCI) is essential for preventing progression toward Alzheimer's disease (AD). In this cross-subject study, we investigate the effectiveness of entropy- and graph-based EEG features for distinguishing MCI from healthy controls (HC), using two modeling approaches: (1) a Transformer network applied to the engineered feature set, and (2) an EEGNet model trained on the same feature representation for comparison. The dataset consists of...
Seizure phenotypes and short-term prognosis in neonatal lupus: a multicenter retrospective cohort in China
Mon, 23 Feb 2026 06:00:00 -0500
CONCLUSIONS: NLE infants with seizures often exhibit focal seizures and structural brain injury, associated with anti-SSA/Ro positivity, limited maternal HCQ exposure, and hematologic abnormalities. Despite good seizure control, developmental delay was frequent, indicating risk for adverse neurodevelopment.
Vestibular epilepsy mimicking recurrent falls: A diagnostic pitfall of incidental sinus pauses
Mon, 23 Feb 2026 06:00:00 -0500
No abstract
The effect of EEG lead configuration on early TMS-EEG artifacts
Mon, 23 Feb 2026 06:00:00 -0500
Transcranial magnetic stimulation (TMS) combined with electroencephalography (EEG) has strong potential for recording cortical reactivity and connectivity. However, this promise is hampered by TMS-induced EEG artifacts. Here, we examine the origins of these artifacts with phantom TMS-EEG recordings and simulations. We focus on two major types of artifacts: (1) the TMS pulse artifact during each ∼0.2 ms TMS pulse and (2) the decay artifact that may last tens of milliseconds. We examine how these...
Treatment of pediatric epilepsy
Mon, 23 Feb 2026 06:00:00 -0500
Pediatric epilepsy is a neurological disorder arising from various etiologies, including structural, genetic, immune, infectious, metabolic, and unknown causes. Anti-seizure medications remain the primary treatment; however, in cases of drug-resistant epilepsy, surgical interventions, ketogenic diet, and emerging therapies have become increasingly effective options. Disease-modifying treatments, such as antisense oligonucleotides and adeno-associated virus-mediated gene replacement, have shown...
Genetic Risk Factors for Epilepsy: From Familial Studies to Gene Discoveries and Polygenic Risk Scores, Strides Toward Unlocking an Age-Old Question in Epilepsy
Mon, 23 Feb 2026 06:00:00 -0500
Article 1: Epileptic encephalopathies are a devastating group of severe childhood epilepsy disorders for which the cause is often unknown. Here, we report a screen for de novo mutations in patients with 2 classical epileptic encephalopathies: infantile spasms (n = 149) and Lennox-Gastaut syndrome (n = 115). We sequenced the exomes of 264 probands, and their parents, and confirmed 329 de novo mutations. A likelihood analysis showed a significant excess of de novo mutations in the ∼4000 genes that...
AES-NINDS Epilepsy Benchmarks Area IV: Comorbidities of Epilepsy - Where Are We and Where Will We Go?
Mon, 23 Feb 2026 06:00:00 -0500
Area IV of the 2021 Epilepsy Research Benchmarks aims to establish research goals to limit or prevent adverse consequences of seizures and their treatment across the life span. In this commentary, we will highlight key advances in Area IV. We will focus here on the comorbidities of epilepsy with special emphasis on neuropsychiatry, the endocrine system, and sudden unexpected death in epilepsy, which were discussed at the Epilepsy Benchmarks Area IV Symposium during the Annual Meeting of the...
MSGM: a multi-scale spatiotemporal graph Mamba for EEG emotion recognition
Mon, 23 Feb 2026 06:00:00 -0500
INTRODUCTION: Electroencephalography (EEG) based emotion recognition is pivotal for advancing mobile health monitoring and real-time affective interaction. However, current methodologies face a critical trade-off between modeling the complex, multi-scale dynamics of brain activity and maintaining the computational efficiency necessary for edge deployment. Existing approaches often rely on fixed temporal scales and neglect hierarchical spatial connectivity, which limits both classification...
Complex temporal network analysis based on the difference visibility graph for epilepsy with and without electrical status epilepticus during sleep (ESES) patients
Mon, 23 Feb 2026 06:00:00 -0500
Epilepsy with electrical status epilepticus during sleep (ESES) is a distinct form of epileptic encephalopathy in childhood, often associated with varying degrees of neurological dysfunction. While previous studies have reported brain functional abnormalities in epilepsy with ESES patients, the specific brain regions and potential neuroelectrical biomarkers remain unclear. This study aims to leverage visibility graph methodology to deeply analyze electroencephalogram (EEG) signals and explore...
Prevalence and associated factors of self-reported lifetime epilepsy symptoms in an older population in Russia: the Ural Very Old Study
Mon, 23 Feb 2026 06:00:00 -0500
CONCLUSION: Self-reported lifetime epilepsy symptoms, experienced at any period of life and assessed using a questionnaire with standardized questions, were reported by 23 of 1,523 participants (1.5%) in this very old population in Bashkortostan. The prevalence was independent of sex, educational level, ethnic background, rural versus urban region of habitation, diabetes mellitus, and arterial hypertension.
Toward precision medicine in SCN3A variants-associated encephalopathies and epilepsy: optimizing genetic diagnosis and molecular subregional effects
Mon, 23 Feb 2026 06:00:00 -0500
CONCLUSION: This study provides systematic benchmarks for algorithms in SCN3A-related DEEs. Integration of reliable algorithms with gene-specific thresholds into clinical variant interpretation pipelines could possibly refine the pathogenicity assessment of missense variants, subsequently informing timely risk stratification and personalized therapeutic strategies for affected patients.
Linking Cortical Morphometry in Self-Limited Epilepsy With Centrotemporal Spikes to Cognition, Function, and Molecular Architecture
Mon, 23 Feb 2026 06:00:00 -0500
CONCLUSION: Collectively, this study provides a novel framework for elucidating the neuroanatomical heterogeneity of epilepsy, offering insights into its behavioral and molecular correlates.
Hemodialysis elevates postoperative seizure risk without worsening overall outcomes after surgical clipping of unruptured intracranial aneurysms
Sun, 22 Feb 2026 06:00:00 -0500
No abstract
Peak width of skeletonized mean diffusivity as a quantitative imaging marker of white matter alterations in MRI-negative temporal lobe epilepsy: validation with demographic covariate adjustment
Sun, 22 Feb 2026 06:00:00 -0500
CONCLUSION: PSMD is a quantitative marker of diffuse white matter pathology in MRI-negative TLE, modulated by demographic factors. Consistent sex effects across groups indicate biological rather than disease-specific variation. Demographic adjustment improves specificity but not overall accuracy, supporting PSMD for group-level cross-sectional studies. Sex effects must be controlled for in white-matter diffusion MRI.
Interictal Epileptiform Discharges propagation revealed by MEG/foramen ovale-EEG co-recording in patients with temporal lobe epilepsy candidate to neurosurgery
Sun, 22 Feb 2026 06:00:00 -0500
OBJECTIVE: The spatio-temporal propagation of the Interictal Epileptiform Discharges (IEDs) can reveal mesial temporal lobe (mTL) involvement in focal temporal seizures. We investigated whether simultaneous recording with magnetoencephalography (MEG), electroencephalography (EEG), and Foramen Ovale Electrodes (FOE) recording improve the definition of the Epileptogenic Zone (EZ) in temporal lobe epilepsies with uncertain lateralization.
Differentiating bipolar disorder and schizophrenia using sleep EEG power and coherence features: A machine learning approach based on polysomnography
Sun, 22 Feb 2026 06:00:00 -0500
Differentiating between bipolar disorder (BD) and schizophrenia (SZ) is challenging due to overlapping clinical symptoms and shared genetic risks, resulting in frequent misdiagnoses and ineffective treatments. This study investigates whether overnight polysomnography (PSG), particularly EEG-derived power spectral and coherence features, can robustly distinguish BD from SZ. We collected PSG data from 196 BD and 154 SZ patients and selected a propensity-score matched cohort of 137 patients per...
EEG-based quantification of chronic pain in cats: A proof-of-concept study using the Piq algorithm
Sun, 22 Feb 2026 06:00:00 -0500
While chronic pain assessment in household pets remains challenging, the use of non-invasive electroencephalography (EEG) in cats has shown promise to identify pain more objectively in this species. A novel EEG-based algorithm - Pain identification and quantification (Piq) - was originally developed in humans to quantify pain intensity. In this proof-of-concept study, the objective was to evaluate whether the Piq algorithm could be explored for feasibility to identify and quantify chronic...
Understanding Participant-Perceived growth and misalignment in an online epilepsy stigma Self-Management Program: A qualitative study
Sun, 22 Feb 2026 06:00:00 -0500
OBJECTIVE: Internalized stigma is a prevalent source of distress among people with epilepsy (PWE), with deleterious effects on psychosocial well-being. RISE ABOVE is a self-paced, online, self-management program designed to help PWE recognize and cope with internalized stigma. This qualitative study explored participant perceptions of growth and misalignment associated with completing RISE ABOVE.
Identification of lateralized cognitive profiles in surgical and nonsurgical pediatric epilepsy patients using the Cognitive Lateralization Rating Index
Sun, 22 Feb 2026 06:00:00 -0500
CONCLUSIONS: This study establishes the generalizability of the CLRI to nonsurgical epilepsy patients and emphasizes the CLRI's ability to detect lateralized profiles in children with epilepsy. Despite significant differences in seizure lateralization, there were no significant differences in cognitive lateralization between surgical and nonsurgical patients.
Low levels of mindfulness in the Epilepsy Monitoring Unit
Sun, 22 Feb 2026 06:00:00 -0500
CONCLUSIONS: Overall mindfulness levels of EMU patients were lower than described in historical healthy controls, and higher mindfulness levels were associated with greater alpha power within the frontoparietal attention network during a mindfulness task.
(Don't) take it personally: EEG markers of preparing lies about autobiographical questions
Sun, 22 Feb 2026 06:00:00 -0500
For millennia, people have been interested in detecting lies and understanding their neurocognitive underpinnings. As a novel approach, the present preregistered EEG study investigates mental processes of preparing a lie, continuing our previous study (Schnuerch, R., Schmuck, J., & Gibbons, H. [2024]. Cortical oscillations and event-related brain potentials during the preparation and execution of deceptive behavior. Psychophysiology, 61[12], e14695.) in a more realistic scenario. While...
Adenosine receptors as emerging therapeutic targets in epilepsy
Sun, 22 Feb 2026 06:00:00 -0500
Epilepsy is one of the most prevalent neurological disorders, and approximately one-third of patients remain resistant to current pharmacological treatments. This underscores the urgent need for innovative therapeutic strategies targeting novel molecular pathways. Among G protein-coupled receptors (GPCRs), adenosine receptors (ARs) have emerged as promising candidates due to their central role in regulating neuronal excitability, neurotransmitter release, and neuroinflammation. Four AR subtypes...
A mega-analysis of EEG-based frontal-midline theta neurofeedback reveals learning dynamics, individual variability, and response profiles
Sat, 21 Feb 2026 06:00:00 -0500
Frontal-midline theta (FM-theta) neurofeedback is a promising approach for enhancing executive control, yet fundamental questions remain regarding its learning dynamics and the sources of interindividual variability, including how FM-theta self-regulation develops over time and which factors shape neurofeedback responsiveness. In this first large-scale mega-analysis of EEG-based neurofeedback, raw participant-level data from five independent international FM-theta neurofeedback studies were...
Safety and efficacy of eslicarbazepine acetate for seizure prevention in patients with stroke at high risk of developing post-stroke epilepsy: a proof-of-concept, phase 2a, randomised, double-blind, placebo-controlled antiepileptogenesis trial
Sat, 21 Feb 2026 06:00:00 -0500
BACKGROUND: Eslicarbazepine acetate is an antiseizure medication that has shown potential antiepileptogenic effects in preclinical models of epilepsy. We aimed to investigate whether eslicarbazepine acetate could prevent or reduce the incidence of unprovoked seizures after acute ischaemic stroke or acute intracerebral haemorrhage.
A step towards antiepileptogenic therapies for post-stroke epilepsy
Sat, 21 Feb 2026 06:00:00 -0500
No abstract
The dynamics of EEG microstates covary with spontaneous thoughts
Sat, 21 Feb 2026 06:00:00 -0500
Brain activity continuously fluctuates alongside the spontaneously co-occurring mental events that comprise our spontaneous thought. Understanding the functional relevance of this intrinsic activity requires investigation of the covariation between ongoing brain dynamics and spontaneous thought. The large-scale electrophysiological events known as electroencephalographic (EEG) microstates provide an important window into the activity of neuronal networks at the millisecond time scale, and...
Novel EEG-based signatures of brain connectivity for imagined speech
Sat, 21 Feb 2026 06:00:00 -0500
Developing effective Brain-Computer Interfaces (BCIs) based on Imagined Speech (IS) is a significant challenge, largely due to high inter-subject variability in neural patterns. This study introduces a novel analytical framework to address this issue by integrating functional, effective, and complex network analyses with a more naturalistic sentence-level experimental protocol. Our findings confirm that while IS connectivity networks are characterized by considerable variability across...
Efficacy and safety of cenobamate-based combination therapy in drug-resistant epilepsy: Secondary analysis by mechanisms of action of concomitant antiseizure medications
Sat, 21 Feb 2026 06:00:00 -0500
CONCLUSION: Cenobamate demonstrated optimal efficacy when combined with valproate and broad-spectrum agents, and suboptimal efficacy when coadministered with SCB. Substantial seizure improvements were often achieved at moderate doses of cenobamate, underscoring the value of individualized titration and comedication management.
EEG recording during visual aura in migraine: Results by quantitative analysis
Sat, 21 Feb 2026 06:00:00 -0500
No abstract
Drug-resistant frontal lobe epilepsy: the role of intranasal EEG records in a patient with frontoethmoidal nasal meningoencephalocele
Sat, 21 Feb 2026 06:00:00 -0500
No abstract
Dose escalation in pentylenetetrazol kindling detects differences in chronic seizure susceptibility
Sat, 21 Feb 2026 06:00:00 -0500
Pentylenetetrazol (PTZ) kindling is a widely used model for inducing epileptogenesis and evaluating long-term seizure susceptibility differences among animals. This model is typically performed by chronic, repetitive exposures to a constant subconvulsive PTZ dose. However, the effectiveness of the commonly used dose (35 mg/kg) varies among different animal groups due to factors such as species, age, sex, and genetic background. This study characterizes a novel kindling approach, the PTZ Dose...
The protective effect of planned pregnancy against adverse foetal outcomes in pregnant women with epilepsy: A retrospective cohort analysis from Northwest China
Sat, 21 Feb 2026 06:00:00 -0500
CONCLUSION: Planned pregnancy is associated with well folic acid adherence, proactive ASM adjustment, higher breastfeeding rates, and stable seizure control. It serves as an independent protective factor against adverse foetal outcomes. Maternal age ≥ 30 years, TPM use, and frequent GTCS increase risk, while ASM withdrawal during pregnancy is not protective.
Early-onset epileptic encephalopathy combined with cerebellar ataxia: A case report expanding the phenotypic spectrum of UBA5-related disorders
Sat, 21 Feb 2026 06:00:00 -0500
No abstract
Advancements in Stem Cell Therapy for Managing Drug-Resistant Epilepsy
Sat, 21 Feb 2026 06:00:00 -0500
Epilepsy is a common chronic disorder of the nervous system and it is typically characterized by repeated seizures that arise from dysregulated electrical activity in the brain. Even with widely used antiseizure drugs and the option of surgery in selected cases, roughly 20 to 30% of patients go on to develop drug-resistant epilepsy, with persistent seizures that are often accompanied by neuronal damage, oxidative stress, and signs of mitochondrial dysfunction. In this context, stem cell therapy...
Robot-assisted versus frame-based stereoelectroencephalography (sEEG) electrode implantation in drug-resistant epilepsy: a meta-analysis of accuracy, efficiency, and safety
Sat, 21 Feb 2026 06:00:00 -0500
CONCLUSION: Robot-assisted sEEG significantly reduced both overall operation time and operation time per electrode compared with the frame-based group. Both techniques demonstrated comparable accuracy and safety profiles.
Default Mode Network Resting State Connectivity Derived From Task-Based fMRI: A Validation Study in People With Epilepsy
Sat, 21 Feb 2026 06:00:00 -0500
CONCLUSION: The intermittent resting state method produces highly similar results to a standard resting state method in people with epilepsy across different aspects of functional connectivity. It is, therefore, an efficient approach to gain insights into functional connectivity networks in a clinical cohort without performing an additional resting state fMRI.
The Dual Associations of Peripheral Inflammatory Cells With Brain Reorganization in Insular Gliomas With/Without Epilepsy: An Exploratory Analysis
Fri, 20 Feb 2026 06:00:00 -0500
OBJECTIVES: The insula was invaded by gliomas and epilepsy occurred frequently. Our study aimed to reveal brain reorganization and explore potential peripheral biomarkers that reflect these processes.
Achieving more human brain-like vision via human EEG representational alignment
Fri, 20 Feb 2026 06:00:00 -0500
Despite advancements in artificial intelligence, object recognition models still lag behind in emulating visual information processing in human brains. Recent studies have highlighted the potential of using neural data to mimic brain processing; however, these often rely on invasive neural recordings from non-human subjects, leaving a critical gap in understanding human visual perception. Addressing this gap, we present, 'Re(presentational)Al(ignment)net', a vision model aligned with human brain...
Characterization of EEG power spectrum correlates of standing and walking in older adults: A scoping review
Fri, 20 Feb 2026 06:00:00 -0500
CONCLUSION: Knowledge synthesized in this review provides insight into the neurobiological mechanisms underlying standing and walking in older adults. The findings of this scoping may lead to developing personalized interventions, such as using non-intensive brain stimulation, to target certain brain activity, which might eventually reduce the risk of falls and disability among older adults.
Screening for Anxiety Symptoms With the Generalized Anxiety Disorder-2 Versus Generalized Anxiety Disorder-7 in Children With Headache or Epilepsy
Fri, 20 Feb 2026 06:00:00 -0500
CONCLUSIONS: Anxiety symptoms were common. Use of the GAD-2 would reduce the number of questions needing completion compared to the GAD-7 for 74% of patients but would fail to identify 11% of patients with moderate-severe anxiety symptoms, including 0.6% of patients with severe anxiety symptoms. These data indicate that the use of the GAD-2 may be appropriate as a briefer alternative to the GAD-7 which may be ideal in clinical settings with a substantial questionnaire burden.
Post-stroke seizure and epilepsy after intravenous alteplase: A retrospective cohort with SeLECT score profiling
Fri, 20 Feb 2026 06:00:00 -0500
CONCLUSIONS: In this retrospective cohort, alteplase exposure was not significantly associated with PSE after adjustment for baseline seizure risk. Although the point estimate suggested a possible increase in PSE risk, the small number of outcome events limits definitive conclusions. Larger prospective studies are needed to better clarify the relationship between thrombolysis and PSE.
Intracranial EEG findings and outcomes in MRI-negative epilepsy with temporal lobe semiology and scalp EEG features
Fri, 20 Feb 2026 06:00:00 -0500
We sought to correlate seizure and cognitive outcomes with seizure onset zones (SOZs) determined from intracranial EEG (iEEG) in patients with MRI-negative drug-resistant focal epilepsy with scalp EEG and semiological features of temporal lobe epilepsy (TLE). We identified 66 patient cases with these imaging, EEG, and semiological characteristics evaluated at the Medical College of Wisconsin from 2002 to 2024. Ictal iEEG data were available for 61 patients. Of these, 25 (41%) had unilateral SOZs...
Motor imagery EEG signal classification using minimally random convolutional kernel transform and hybrid deep learning
Fri, 20 Feb 2026 06:00:00 -0500
The brain-computer interface (BCI) establishes a non-muscle channel that enables direct communication between the human body and an external device. Electroencephalography (EEG) is a popular non-invasive technique for recording brain signals. It is critical to process and comprehend the hidden patterns linked to a specific cognitive or motor task, for instance, measured through the motor imagery brain-computer interface (MI-BCI). A significant challenge is presented by classifying motor...
Exploring the neural processing mechanisms of umami peptides: Insights from high-temporal-resolution electroencephalogram (EEG) analysis
Fri, 20 Feb 2026 06:00:00 -0500
This study used electroencephalography to characterize brain responses to the umami peptide RPIEK (0.75, 1.50, and 3.00 mg/mL) and matched monosodium glutamate solutions (0.10, 0.50, and 1.00 mg/mL), focusing on oscillatory dynamics, cortical regions, and spatiotemporal response profiles. The results demonstrated that RPIEK significantly increased (P < 0.05) area under the curve of the power spectral density, with delta and theta band activity principally encoding umami information. Brain can...
Practice variability in vagus nerve stimulation settings for drug-resistant epilepsy and a pilot quality improvement initiative to optimize stimulation parameters
Fri, 20 Feb 2026 06:00:00 -0500
CONCLUSIONS: Substantial practice variability in VNS parameter settings with suboptimal utilization of therapy existed, which improved following introduction of the pilot intervention. Standardized protocols can ensure timely delivery of therapeutic parameters. These strategies have been underutilized in earlier studies, likely overestimating the time to response from VNS therapy.
Beyond the Numbers: Advocating for an Integrative Analysis of Raw and Processed Electroencephalography Metrics
Fri, 20 Feb 2026 06:00:00 -0500
No abstract
Maternal Diabetes Associated With Increased Risk of Epilepsy in Children
Fri, 20 Feb 2026 06:00:00 -0500
No abstract
Ozone Treatment Attenuates Neuroinflammation and Alters miRNA Expression in a Rat Model of Post-Traumatic Epilepsy
Fri, 20 Feb 2026 06:00:00 -0500
The aim of this study was to investigate the effects of intraperitoneal ozone therapy in a post-traumatic epilepsy (PTE) model. An in vivo PTE model was established in male Sprague-Dawley rats, which were randomised to control (n = 8), PTE (n = 10), and PTE + Ozone (n = 10) groups. 0.7 mg/kg ozone was administered intraperitoneally for 3 consecutive days. Seizure activity was video recorded for 120 min and evaluated for latency, frequency, duration, and severity. Behavioral assessments of...
Bridging Neural Topology and Affective Computing: Graph Attention for EEG Emotion Recognition
Fri, 20 Feb 2026 06:00:00 -0500
Electroencephalography (EEG) offers high temporal resolution and strong physiological validity for emotion recognition. However, complex spatial organization and inter-subject variability present major modeling challenges. Graph-based spatial attention mechanisms have emerged as a key solution, preserving brain topological priors while adaptively emphasizing emotion-relevant regions and connections. This review summarizes advances in graph convolutional networks (GCN) and graph attention...
Recurrent nocturnal tongue biting mimicking epilepsy: a case report of severe obstructive sleep apnea
Fri, 20 Feb 2026 06:00:00 -0500
No abstract
Clinical vignette: Generalized epilepsy associated with TRMT1 mutation in two siblings
Fri, 20 Feb 2026 06:00:00 -0500
No abstract
Interactive and open educational resources for advanced EEG analysis
Fri, 20 Feb 2026 06:00:00 -0500
No abstract
Expanding the phenotypic spectrum of CACNA1A-related developmental and epileptic encephalopathy in adults
Fri, 20 Feb 2026 06:00:00 -0500
Deleterious variants in the CACNA1A gene, encoding the CaV2.1 P/Q-type voltage-gated calcium channel, cause a broad spectrum of neurological disorders, including familial hemiplegic migraine, episodic ataxia, and developmental and epileptic encephalopathy (DEE). Information on genotype-phenotype correlations and on the factors influencing clinical variability is still limited, hindering potential applications in precision medicine. We present three adults (aged 26, 27, and 40 years) from two...
Epilepsy-Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Fri, 20 Feb 2026 06:00:00 -0500
OBJECTIVE: Pathogenic variants in SCN1A, which encodes the voltage-gated sodium channel Na(V)1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss-of-function, whereas neonatal/infantile-onset developmental and epileptic encephalopathy (DEE) is associated with gain-of-function. Strategies to predict SCN1A variant pathogenicity and dysfunction have...
Genetic-Epigenetic Interplay in Epilepsy: Pathways, Biomarkers, and Epigenome-Targeted Therapies
Fri, 20 Feb 2026 06:00:00 -0500
Epilepsy is a heterogeneous neurological disorder with a strong genetic basis, yet recent evidence underscores the critical role of epigenetic mechanisms in its pathogenesis. This review synthesizes current knowledge on how chromatin remodeling, histone modifications, DNA methylation, and transcriptional regulation intersect with classical channelopathies and signaling pathways. We emphasize how epigenetic dysregulation contributes to neuronal excitability and network plasticity, particularly...
Dihydroartemisinin Alleviates Neuronal Damage and Seizures in Epileptic Mice by Inhibiting Ferroptosis via the SIRT1/FOXO1/SLC7A11/GPX4 Pathway
Fri, 20 Feb 2026 06:00:00 -0500
CONCLUSION: In summary, our findings indicate that DHA may have antiepileptic and neuroprotective benefits by suppressing ferroptosis through the SIRT1/FOXO1/SLC7A11/GPX4 signaling pathway.
Active Task Engagement Enhances Auditory Brain-Behaviour Prediction From Single-Trial EEG Compared With Passive Listening
Fri, 20 Feb 2026 06:00:00 -0500
Auditory neural processing during active task engagement and passive listening reflects distinct task contexts with potentially different behavioural relevance. While both contexts elicit deviance-related responses, it remains unclear, which yields neural measures that more reliably predict individual differences in behavioural performance. To address this question, we employed a multi-feature auditory paradigm in which frequency, duration, and intensity deviants were presented under passive (no...
Quantitative Electroencephalographic (qEEG) Characterisation and Biomarker Identification of Generalised Paediatric Seizure Using Spectral Features
Fri, 20 Feb 2026 06:00:00 -0500
CONCLUSION: The study reveals a complex pattern of characteristic quantitative electroencephalographic (qEEG) alterations in the paediatric seizure population suggestive of significant neurophysiological implications, including alterations in arousal, attention and inhibitory control mechanisms and the features may be of some value in objective seizure assessment using EEG.
Transcranial magnetic stimulation in cocaine use disorder and the risk of seizure: a review of the evidence
Fri, 20 Feb 2026 06:00:00 -0500
Transcranial magnetic stimulation (TMS) has emerged as a promising intervention for cocaine use disorder (CUD). However, a key concern when employing TMS in CUD is the potential risk of seizures. Our goal was to assess seizure risk in individuals with CUD undergoing TMS and to propose parameters that could mitigate it. Our review of the literature indicated that seizures are primarily associated with high-dose cocaine use necessitating urgent medical care - and that the risk is likely low...
Explainable AI uncovers novel EEG microstate candidate neurophysiological markers for autism spectrum disorder
Fri, 20 Feb 2026 06:00:00 -0500
CONCLUSION: The findings from the study demonstrated that microstate-informed features capturing temporal instability, transition unpredictability, and spectral alterations serve as clinically relevant and interpretable candidate neurophysiological markers of ASD, offering translational potential for objective diagnosis, treatment monitoring, and personalized interventions.
Levetiracetam as First-Line Anti-seizure Medicine in Electrographically Confirmed Neonatal Seizures: A Literature Review
Fri, 20 Feb 2026 06:00:00 -0500
Phenobarbitone (PHB), the recommended first-line anti-seizure medicine (ASM) in neonatal seizure (NS), has many side effects needing monitoring and management; therefore, it may not be a good choice in low-to-middle-income countries (LMICs) with poor facilities. Levetiracetam (LEV), an emerging ASM in NS with a good short-term safety record, is evaluated with or without a comparator ASM as a first-line ASM. Using strict inclusion and exclusion criteria, a comprehensive literature search was...
TMS-EEG signatures of motor network dysfunction in multiple sclerosis
Fri, 20 Feb 2026 06:00:00 -0500
Multiple sclerosis (MS) progressively impairs brain network function, often driving disability even in the absence of overt structural MRI changes. Current clinical and radiological tools frequently fail to capture early, subtle disruptions in cortical activity that may indicate ongoing disease progression. Functional assessment methods capable of detecting these early network alterations are therefore critically needed. This study aimed to determine whether brain responses recorded by combining...
Recurrent syncope due to ischemic ventricular tachycardia masquerading as a seizure disorder treated with coronary revascularization: a case report
Fri, 20 Feb 2026 06:00:00 -0500
CONCLUSION: This case highlights ischaemia-associated ventricular tachycardia as a potentially reversible cause of syncope that may mimic seizures. Improvement was observed after revascularization, though the mechanism remains inferred and may have been influenced by concomitant amiodarone. Clinicians should consider cardiac arrhythmias in atypical seizure-like episodes, especially in adults with cardiovascular risk factors.
The Blind Leading the Uncontrolled: How Does Seizure Frequency Improve Over Time in Drug-Resistant Epilepsy?
Fri, 20 Feb 2026 06:00:00 -0500
No abstract
Effect of ABCG2 genetic polymorphisms on the transport of anti-seizure medications in hCMEC/D3 cell lines
Fri, 20 Feb 2026 06:00:00 -0500
The ATP-binding cassette, subfamily G, member 2 (ABCG2) transporter, or breast cancer resistance protein (BCRP), plays a crucial role in the absorption and distribution of various compounds, including anti-seizure medications (ASMs). ABCG2 genetic polymorphisms have been shown to affect the pharmacokinetics of several drugs, including anti-cancer drugs and statins. Clinical studies suggested an association between the ABCG2 variations and ASMs pharmacokinetics. Thus, the aim of the present study...
Epilepsy Phenotypic Spectrum of NUS1-Related Disorder: A Case Series
Fri, 20 Feb 2026 06:00:00 -0500
CONCLUSION: Taken together, NUS1 variants are associated with generalized epilepsy phenotype and an invariant EEG pattern of monomorphic theta activity.
Prognostic factors and a preliminary prognostic model in anti-GAD antibody-associated epilepsy
Fri, 20 Feb 2026 06:00:00 -0500
CONCLUSION: Focal seizures, TLE, and higher seizure frequency were associated with poor prognosis, whereas early diagnosis, timely treatment, and higher peripheral CD8^(+)T-cell counts were associated with favorable outcomes. TLE and seizure frequency independently predicted clinical outcomes in anti-GAD antibody-associated epilepsy. The logistic regression model effectively stratified patients, identifying those likely to achieve seizure freedom versus refractoriness.
RETRACTION: a 1D CNN for high accuracy classification and transfer learning in motor imagery EEG-based brain-computer interface (2021J. Neural Eng. 18 066053)
Fri, 20 Feb 2026 06:00:00 -0500
No abstract
AI in epilepsy neuroimaging
Fri, 20 Feb 2026 06:00:00 -0500
PURPOSE OF REVIEW: Recent advances in the capabilities and usability of artificial intelligence (AI) architectures coupled with increased availability of neuroimaging datasets has fuelled a rapid expansion in AI applications to epilepsy neuroimaging. This review summarizes the main applications of AI in epilepsy neuroimaging and suggests future directions for the field.
A Clinical Scoring Tool for Predicting Epilepsy in Children With First-Onset Afebrile Seizure in the Emergency Department: A Retrospective Observational Study
Thu, 19 Feb 2026 06:00:00 -0500
CONCLUSIONS: This clinical scoring tool may help stratify epilepsy risk in children with first-onset afebrile seizures in the ED. If prospectively validated, it could help identify high-risk patients early for appropriate referral and follow-up without requiring specialized equipment such as electroencephalography, thereby supporting clinical decision-making.
Ketogenic Diet as an Epigenetic Therapy in SETD1B-Related Epilepsy
Thu, 19 Feb 2026 06:00:00 -0500
Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4-year-old boy with SETD1B-related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified Atkins ketogenic diet. Single-cell RNA sequencing of 25,159 peripheral mononuclear cells across 3 samples: baseline, 3 months on-diet and age-matched...
Crotonylation of STXBP1 exacerbates seizure susceptibility by impairing GABAergic synaptic transmission
Thu, 19 Feb 2026 06:00:00 -0500
Temporal lobe epilepsy (TLE) is the most common and severe form of epilepsy in adults; however, the underlying pathological mechanisms remain unclear. Post-translational modifications (PTMs) of proteins are increasingly recognized to contribute to the development and maintenance of epilepsy; however, the functional significance of lysine crotonylation (Kcr) in epilepsy formation is still unclear. Herein we found that high levels crotonylation promote seizure susceptibility. Through quantitative...
Role of microtubule affinity-regulating kinases in epilepsy: A novel therapeutic strategy
Thu, 19 Feb 2026 06:00:00 -0500
CONCLUSION AND IMPLICATIONS: MARK1/2-mediated excitatory synaptic transmission plays a key role in the development of epilepsy. Pharmacological inhibitors of MARKs, such as PCC0105003, may represent a novel therapeutic strategy for the management of epilepsy.
Long-term outcome in children with infantile epileptic spasms syndrome: a multicenter retrospective study in Korea
Thu, 19 Feb 2026 06:00:00 -0500
CONCLUSION: The IESS imposes a substantial burden on affected children and their families and often leads to chronic epilepsy and impaired cognitive function. Consensus diagnostic and treatment guidelines tailored to the Korean clinical practice are necessary to ensure early diagnosis and timely treatment.
Preoperative positron emission tomography for predicting postoperative epilepsy risk: A radiomics and clinical feature-based fusion model
Thu, 19 Feb 2026 06:00:00 -0500
CONCLUSION: The integration of radiomics and clinical features provides a more accurate and clinically useful tool for predicting postoperative epilepsy risk. The fusion model demonstrates significant potential in guiding clinical decision-making and personalized treatment for epilepsy patients.
Post stroke seizures and Vascular epilepsy
Thu, 19 Feb 2026 06:00:00 -0500
CONCLUSION: This study emphasizes the need for clear guidelines for managing post-stroke epilepsy, especially for high-risk elderly patients. Current recommendations provide useful insights, but further research is needed to better define risk factors and optimize management strategies.
Bimodal EEG-fNIRS and Deep Learning for Classifying Intensity-Dependent Cortical Auditory Evoked Responses
Thu, 19 Feb 2026 06:00:00 -0500
Detection of intensity-dependent cortical auditory evoked responses using electroencephalography (EEG) is essential in clinical audiology and research on neurological disorders. While EEG remains the gold standard for monitoring brain activity, functional near-infrared spectroscopy (fNIRS) has emerged as a complementary modality, offering distinct insights into cortical responses. This study investigates the added value of fNIRS in classifying cortical responses to auditory stimuli across five...
Associations among epilepsy phenotypes and pain, sleep interference, and dissociative symptoms
Thu, 19 Feb 2026 06:00:00 -0500
CONCLUSION/IMPLICATIONS: Among VWE, some epilepsy phenotypes may account for independent risk beyond demographic and injury characteristics for pain and sleep interference. These findings underscore the importance of targeted assessment and intervention strategies tailored to specific comorbidity profiles in the management of pain and sleep difficulties among VWE. (PsycInfo Database Record (c) 2026 APA, all rights reserved).
AAV-mediated gene therapy in a SLC13A5 citrate transporter disorder model rescues epileptic and metabolic phenotypes
Thu, 19 Feb 2026 06:00:00 -0500
SLC13A5 citrate transporter disorder is a rare epileptic encephalopathy caused by loss of function pathogenic variants in the SLC13A5 gene. Loss of sodium/citrate cotransporter (NaCT) function causes a severe early life epilepsy resulting in life-long developmental disabilities and increased extracellular citrate. Current antiseizure medications may reduce seizure frequency, yet more targeted treatments are needed to address the epileptic and neurodevelopmental SLC13A5 phenotype. We performed...
Detection of regional metabolic alteration using 7T deuterium metabolic imaging in MRI-negative, (18)FDG-PET-positive epilepsy patients
Thu, 19 Feb 2026 06:00:00 -0500
CONCLUSIONS: Ultra-high-field DMI revealed elevated hippocampal glutamatergic turnover in MRI negative epilepsy patients, with the highest levels in the epileptogenic hippocampus. These findings indicate the presence of subtle metabolic alterations in hippocampal tissue, supporting the potential of DMI to capture pathophysiological changes that remain invisible to conventional imaging.
Spurious Spike Elimination using Sparse Signal Processing Improves Seizure Onset Zone Delineation in Brief Intraoperative iEEG Recordings
Thu, 19 Feb 2026 06:00:00 -0500
Interictal epileptiform spikes and high frequency oscillations (HFOs) have proven to be promising neuro biomarkers for seizure onset zone (SOZ) identification in drug-resistant epilepsy. This study presents a sparse signal processing based denoising model for epileptiform spikes. The model was trained on expert-labeled events to remove artifacts and spurious detections from the initial candidate spike pool captured using an amplitude threshold-based detector. We hypothesize that interictal...
Bitemporal Lobe Epilepsy: Evolving Diagnostic and Treatment Paradigms
Thu, 19 Feb 2026 06:00:00 -0500
Bilateral temporal lobe epilepsy (BTLE) represents a challenging subset of drug-resistant epilepsy, accounting for 20-35% of temporal lobe epilepsy cases. Characterized by independent seizure onset from both temporal lobes, BTLE complicates diagnosis and treatment due to the difficulty in precisely localizing seizure onset zones (SOZs) and its profound cognitive and quality-of-life impact. Memory impairment and frequent seizures significantly burden patients, necessitating advanced diagnostic...
Benchmarks to Breakthroughs: How the 2007 Epilepsy Research Benchmarks Reframed Scientific and Clinical Trajectories of 21st-Century Epilepsy Care
Thu, 19 Feb 2026 06:00:00 -0500
No abstract
That Sync-ing Feeling: The Progressive Drop of Hippocampal and Entorhinal Coordination in Murine Epilepsy
Thu, 19 Feb 2026 06:00:00 -0500
No abstract